Science

Research: Astronauts' gut health

The so-called "gut-brain axis" is the well-established bidirectional interaction between the gut microbiome and the brain. In other words, the microbiome in our gut has been found to influence many aspects of our brain: stress physiology and psychology, mood, cognition, and behavior.

A novel challenge has arisen from this finding. Namely, how can astronauts stay alert and healthy through their travels? 

One issue is the inadequate intake of micronutrients, which is generally associated with increased inflammation and stress. It also leads to reduced functioning of the immune system. Although the space travelers’ diet is not yet optimized, considerable progress has been made. For instance, the average caloric intake has been significantly increased in recent years.

Harvesting human cells from animals

CNN reports that scientists have created a mouse embryo that's 4% human. The hybrid is what scientists call a human-animal chimera, a single organism that is made up of two different sets of cells. This human-mouse chimera has by far the highest number of human cells ever recorded in an animal.

The team's experiment indicates that there is enough evolutionary compatibility between mice and humans that mouse embryos are a relatively good environment for cultivating human cells. This breakthrough could potentially generate better mouse models to study human diseases, including Covid-19. Mice can also be used to grow human immune cells or respiratory cells.

Where does consciousness come from?

According to BigThink, a publication focused on education, what consciousness is and where it comes from has absorbed great minds for thousands of years. In today's world, it's a question posed by physicists, cognitive scientists, and neuroscientists. There are a few prevailing theories.

The first is known as materialism. This is the idea that consciousness emanates from matter. In the case of people, by the firing of neurons inside the brain. If you take the brain out of the equation, then consciousness doesn't exist at all.

The second theory is mind-body dualism. This is perhaps more often recognized in religion. Here, consciousness is separate from matter. It is a part of another aspect of the individual, which in religious terms we might call the soul.

An explosion of stellar proportion

Global News, a Canadian news outlet, reported that astronomers detected an explosion over fifteen times the size of our galaxy. This makes it the biggest blast ever recorded.

The massive explosion occurred hundreds of millions of light-years away, where a supermassive black hole emitted large amounts of energy and matter while devouring a galaxy, blowing a hole in space that’s 2.58 million light-years across. It wiped out trillions of stars and tore through the surrounding galaxies. Researchers spotted the hole from the colossal gap it left in the middle of a cluster of galaxies.

The blast occurred in the Ophiucus cluster, a collection of galaxies some 390 million light-years away. It’s unclear exactly when the explosion happened, but researchers say it was definitely millions of years ago.

The ancient girl who ate hazelnuts

According to CNN, in late 2019, a small piece of birch pitch (pictured above) was found by archeologists on Lolland, the fourth largest island of Denmark. A study uncovered a 5,700-year-old girl's entire genome and oral microbiome, marking the first time human genetic material has successfully been extracted from something besides human bones.

Nicknamed Lola, the young girl who chewed on the birch pitch had blue eyes, dark skin and dark hair. Her last meal included hazelnuts and mallard duck but no milk. She was lactose-intolerant, which serves to validate the theory that adults evolved the tolerance after dairy farming was introduced.

Prime editing diseases away

The BBC reports that a new way of editing DNA could correct 89% of the errors in DNA that cause disease. The technology, called prime editing, has been used to correct damaging DNA mutations in the lab, including those that cause sickle cell anaemia. It is the latest advance in gene editing, which is developing at a rapid pace.

DNA is found in nearly all of our cells, and gene editing is already changing scientific research with the promise of revolutionizing medicine. Nevertheless, deep moral and ethical questions arose after the creation of babies who were gene-edited to have protection from HIV.

Crispr-Cas9, a technology which was developed just seven years ago, scans DNA for the right spot and then cuts it in two, which creates the opportunity to edit the DNA. A study used prime editing to accurately insert or delete sections of DNA and to correct typos in a single "letter" out of the three billion that make up the human genetic code.

Saving the world with batteries

The 2019 Nobel Prize in chemistry has been awarded to three scientists who played a large role in developing lithium-ion batteries: Stanley Whittingham of the U.K., American John Goodenough (at 97, the oldest Nobel laureate ever), and Japan’s Akira Yoshino. Whittingham created the first functional lithium-ion battery in the 1970s, then Goodenough increased its capacity two-fold over the next 10 years. Finally, Yoshino removed the pure lithium, making it much safer to use.

Lithium-ion batteries are indispensable in today’s world, used in everything from cellphones to cordless power tools to electric cars. Rechargeable and able to store large amounts of energy, they have revolutionized electronics. As the Nobel Committee put it, "...this year’s chemistry laureates have laid the foundation of a wireless, fossil fuel-free society."

First, do no harm

Mathematicians, computer engineers and scientists in related fields should take a Hippocratic oath to protect the public from powerful new technologies under development, says Hannah Fry, an associate professor of mathematics at University College, London. The ethical pledge would commit scientists to think deeply about the possible applications of their work and compel them to pursue only those that, at the least, do no harm to society.

“We need a Hippocratic oath in the same way it exists for medicine,” Fry said. “In medicine, you learn about ethics from day one. In mathematics, it’s a bolt-on at best. It has to be there from day one and at the forefront of your mind in every step you take.”

Origami of the future

Recently, the ancient art of origami has begun to merge with modern engineering. Origami principles have inspired novel ways of packaging airbags, fashioning heart stents, folding solar sails designed to propel spacecraft, and even collapsible bullet-proof shields. 

Modern research in origami began in 1970 when an astrophysicist named Koryo Miura came up with a simple but elegant fold. Known as the Miura fold, or Miura-ori, he later repurposed the fold as a way to package large, flat membranes for deploying into space. In 1995, a Japanese satellite used the fold to store its solar panels for launch and unfurl them once in orbit.

Squid skin inspires new material

“Ultra-lightweight space blankets have been around for decades, but the key drawback is that the material is static," said Alon Gorodetsky, UCI associate professor of chemical & biomolecular engineering. "We've made a version with changeable properties so you can regulate how much heat is trapped or released."

The researchers took design cues from various species of squids, octopuses and cuttlefish that use their adaptive skin to thrive in aquatic environments.

The skin cells can instantly change from minute points to flattened disks. "We use a similar concept in our work, where we have a layer of these tiny metal 'islands' that border each other," said Erica Leung, a UCI graduate student in chemical & biomolecular engineering.

The new science of sex and gender

Sex is supposed to be simple, at least at the molecular level. X + X = female and X + Y = male.

But as science looks more closely, it becomes increasingly clear that a pair of chromosomes is not always sufficient to distinguish girl/boy—either from the standpoint of sex (biological traits) or of gender (social identity).

In the cultural realm, this shift in perspective has received a wide embrace, with “nonbinary” definitions of gender—transfeminine, genderqueer—having already entered the vernacular. Less visible are the changes taking place in the biological sciences.

The emerging picture of “girlness” or “boyness” reveals the involvement of complex gene networks, extending far beyond the moment six weeks after gestation when the gonads begin to form.

To different extents, many of us are biological hybrids on a male-female continuum. New evidence suggests that the brain consists of a “mosaic” of cell types.

How much does a kilogram weigh?

A small cylinder called Le Grand K has defined the kilogram for more than a hundred years.

Le Grand K was forged in 1879 and is held in a locked vault outside Paris—revered and kept under lock and key because its mass, a little over 2 pounds, is the official definition of the kilogram.

If Le Grand K gets heavier or lighter—or absorbs atoms of something from the air—the definition of the kilogram literally changes.

Bill Phillips, a Nobel laureate from the National Institute of Standards and Technology in Maryland, told the assembled delegates at the international General Conference on Weights and Measures that basing the kilogram's official definition on a hunk of metal held in a vault was "a situation that is clearly intolerable." His colleagues clearly agreed, as no country voted to keep the old definition. 

Europe and Japan go to Mercury

A European-Japanese spacecraft set off on a treacherous seven-year journey to Mercury to probe the solar system's smallest and least-explored planet.

The BepiColombo mission, only the third ever to visit Mercury, blasted off from Europe’s spaceport in French Guiana aboard an Ariane 5 rocket at 10:45 p.m. local time on Friday, October 19 (0145 GMT on Saturday), according to the Japan Aerospace Exploration Agency (JAXA).

Few spacecraft have visited Mercury because of the planet's proximity to the sun—less than 60 million kilometers (37.3 million miles) away compared with Earth's almost 150 million kilometers (93 million miles)—which makes any trip there challenging. Surface temperatures on the planet can reach highs of over 400℃ (750℉) during the day and drop to -170℃ (-275℉) at night.

Japan lands rovers on asteroid

Japan landed two unmanned rovers on a 1-kilometer-wide asteroid named Ryugu in late September, 2018. It was the first time robot rovers have successfully landed on an asteroid surface.

"I felt awed by what we had achieved in Japan. This is just a real charm of deep space exploration," Takashi Kubota, a spokesman for the space agency, told CNN. The two rovers together are called MINERVA-II1 and came from the spacecraft Hayabusa2.

The rovers hop and float across the asteroid—thanks to its low gravity—to capture information including photos and the asteroid's temperature. Since landing, the rovers have sent back photos and data. This asteroid is believed to be a particularly early one, with a wealth of water and organic material that will shed light on the "Building blocks of Earth."

American & Japanese win Nobel prize

Two scientists who discovered how to harness the body’s immune system to fight cancer won the 2018 Nobel prize in physiology or medicine. James Allison, of the US, and Tasuku Honjo, of Japan, shared the 9m Swedish kronor ($1m/¥113m) prize.

The scientists’ groundbreaking work on the immune system has paved the way for a new class of cancer drugs that are already dramatically changing outcomes for patients. It is the first time the development of a cancer therapy has been recognised with a Nobel prize.

Allison said he was in a “state of shock” about having achieved “every scientist’s dream”. “I’d like to give a shout out to all the [cancer] patients out there to let them know we’re making progress here,” he said.

Honjo, who began his research after a medical school classmate died from stomach cancer, said: “I want to continue my research...so that this immune therapy will save more cancer patients than ever.”

New planets discovered

Scientists have recently discovered two exoplanets, Kepler-62f and Kepler 186f, which are located within the habitable zones of their respective stars, and the best part is that the planets probably have stable climates and regular seasons. The astronomers also believe that one of them is similar in size to our home planet. 

Researchers from the Georgia Tech and Harvard University found out that both Kepler-186f and Kepler-62f seem to be steadily tilted on their axis, just like Earth, giving them stable climates and seasons. "Our calculations show that their spin would have remained constant over tens of millions of years," said Georgia Tech's Assistant Professor Gongjie Li. According to the scientists, these exoplanets are capable of harboring life.

The Great Pacific Garbage Patch

In the summer of 2019, French swimmer and anti-plastic campaigner Ben Lecomte swam through the giant floating rubbish mass known as the Great Pacific Garbage Patch. 

The exact size of the Great Pacific Garbage Patch is impossible to determine, but estimates put it anywhere from 700,000 to 15,000,000 km² (or the size of Texas to the size of Russia). The patch is caused by the North Pacific gyre—a circle of currents that keep plastic, waste and other pollution trapped. According to scientists, the Patch has been growing “exponentially” in recent years.

Lecomte and his support team sampled the water they swam through every day of the journey, gauging the level of plastic and microplastic pollution. As the expedition’s first mate, Tyral Dalitz, said, “The ocean is now filled with microplastics. Rather than calling it an island of trash, it is more like plastic smog throughout the ocean.” 

Rare earths discovered in Japan

Every day, we use products that are built using “rare earths”—a group of 17 elements that are, as the name suggests, very rare. They’re used to make everyday items such as rechargeable batteries, LED lights and display panels, as well as larger products such as wind turbines.

Now, it turns out, Japan has an estimated 16 million tons of the stuff on its turf. Researchers claim the trove might be enough to supply the world with metals such as yttrium and europium on a “semi-infinite basis.”

This is good news for Japan’s industrial sector. The world’s biggest source of rare earths is by far China, which has in the past halted exports to Japan when the two countries have been at odds.

Floating away anxiety and stress

When I mentioned to a friend that my baseline neurosis had evolved from daily stress into anxiety, her response was, "Go for a float!"

A float?

Yes — spend an hour in a dark, soundproof room floating in a salted, body-temperature warm pool. "You just lie there and meditate," my friend told me.

As a doctor wary of overprescribing medications, I was intrigued by the idea that floating could combat stress and anxiety. So, I looked to see if there was any science to back up this claim. I visited the lab of neuropsychologist Justin Feinstein at the Laureate Institute for Brain Research, who is investigating float therapy as a nonpharmacological treatment for people with conditions like anxiety and depression.

Feinstein asked if I wanted to try it. So, after a quick shower, I jumped right in. It took a while to let my thoughts quiet down, but eventually I was so relaxed I fell asleep — while floating!